翻訳と辞書 Words near each other ・ Heat pump and refrigeration cycle ・ Heat Radio ・ Heat rate ・ Heat rate (efficiency) ・ Heat recovery steam generator ・ Heat recovery ventilation ・ HEAT repeat domain ・ Heat rock ・ Heat rub ・ Heat Rush ・ Heat sealer ・ Heat Seekers ・ Heat shield ・ Heat Shield Rock ・ Heat shock ・ Heat shock factor ・ Heat shock protein ・ Heat shock protein 47 ・ Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) ・ Heat shock protein 90kDa alpha (cytosolic), member A1 ・ Heat sink ・ Heat sink (disambiguation) ・ Heat spreader ・ Heat stabilization ・ Heat storage ・ Heat stroke ・ Heat syncope ・ Heat Team ・ Heat therapy ・ Heat torch Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Heat shock factor ： ウィキペディア英語版 Heat shock factor Heat shock factor (HSF), in molecular biology, is the name given to transcription factors that regulate the expression of the heat shock proteins. A typical example is the heat shock factor of ''Drosophila melanogaster''. == Function == Heat shock factors (HSF) are transcriptional activators of heat shock genes.〔 These activators bind specifically to Heat Shock sequence Elements (HSE) throughout the genome whose consensus-sequence is a tandem array of three oppositely oriented "AGAAN" motifs or a degenerate version thereof. Under non-stressed conditions, Drosophila HSF is a nuclear-localized unbound monomer, whereas heat shock activation results in trimerization and binding to the HSE. The Heat Shock sequence Element is highly conserved from yeast to humans. Heat shock factor 1 (HSF-1) is the major regulator of heat shock protein transcription in eukaryotes. In the absence of cellular stress, HSF-1 is inhibited by association with heat shock proteins and is therefore not active. Cellular stresses, such as increased temperature, can cause proteins in the cell to misfold. Heat shock proteins bind to the misfolded proteins and dissociate from HSF-1. This allows HSF1 to form trimers and translocate to the cell nucleus and activate transcription. Its function is not only critical to overcome the proteotoxic effects of thermal stress, but also needed for proper animal development and the overall survival of cancer cells. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Heat shock factor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.